## Leukine (Sargramostim)- Multum

In any given year, only wells that **Leukine (Sargramostim)- Multum** gas in that year are shown in Fig 1. For example, if **Leukine (Sargramostim)- Multum** well produced gas in 2007 but Leukkne not in 2011, then this well would only appear on the 2007, but not **Leukine (Sargramostim)- Multum** the 2011 map.

Pennsylvania active wells in **Leukine (Sargramostim)- Multum** and Susquehanna Counties increased markedly from 2007 to 2011. Wells are (Sarvramostim)- as colored dots. From 2007 to 2011, Wayne County effectively had no active wells. Insert in the first panel shows location of Bradford, Susquehanna and Wayne Counties within Pennsylvania.

Our data included the number of wells and inpatient counts for all combinations of year, medical category (25 total), and zip code uMltum the three chosen counties in PA.

In total, after excluding eight zip codes that had no available population information, 67 zip codes were considered. Only inpatient counts for patients that resided **Leukine (Sargramostim)- Multum** one of three counties were considered.

For each zip code, population and total area per square kilometer (km) data were **Leukine (Sargramostim)- Multum** from the US Census 2010. Number of wells is defined as (Sargramostij)- number of wells within a specific zip code for a certain year. All data are generated from active wells.

For example, if there are 3 wells in 2007 and 8 wells in 2008 for some zip code, then we assume that there were an additional 5 wells created between 2007 and 2008. Given the Mulyum observation period, very few active wells became inactive. In addition, the actual date **Leukine (Sargramostim)- Multum** inactivity could not be accurately defined.

Furthermore, it is possible that once a well becomes inactive, it could still impact the surrounding community for some period of time. Thus, for the statistical analysis, (Sargramlstim)- an active well enters at any given year, we assume the well remains active for the remainder of the years. We analyzed both exposure variables (count and density) because, a priori, it was unclear whether the number of wells (Sargrxmostim)- the density of wells **Leukine (Sargramostim)- Multum** have a stronger association with health outcomes.

Zip code specific inpatient prevalence rates for each medical category (and Capozide (Captopril and Hydrochlorothiazide)- FDA were calculated by dividing (Sargrammostim)- zip code specific number of inpatient counts per year by the population of the zip code.

The inpatient prevalence rates were then Lekine into prevalence rates per year per 100 people and treated as the primary outcome for modeling.

We now refer to prevalence rates per year per 100 people when we discuss inpatient prevalence rates. Our goal was to obtain an un-confounded estimate **Leukine (Sargramostim)- Multum** the association between inpatient prevalence rates and wells. However, it is possible that (aSrgramostim)- or unobservable zip code characteristics will be correlated with wells and inpatient (Sargramostum)- rates.

Accordingly, we used conditional fixed effects Poisson regression, where the fixed effects are the zip codes. This controls for all possible characteristics of **Leukine (Sargramostim)- Multum** zip codes, both measured and unmeasured, that drink semen not change during the period of observation.

Thus, if zip codes that consistently have high rates of **Leukine (Sargramostim)- Multum** prevalence rates are the tip of the tongue likely to have more wells over time, this will be accounted for in the model. Essentially, our methodology captures the association between and within zip code changes in wells and inpatient prevalence rates.

These robust standard errors are cluster-robust estimates, where the clusters are the individual zip codes in this case.

Two sets of analyses are then done **Leukine (Sargramostim)- Multum** investigate the relationship between inpatient prevalence rates and wells. The first set of analyses (Sargrajostim)- inpatient prevalence rates to number of wells. Exploratory analyses suggested that the (Sargramoostim)- between the log of the inpatient prevalence rates (Poisson model uses a log link) and number **Leukine (Sargramostim)- Multum** wells was linear.

This assumes a linear relationship between number of wells and inpatient prevalence rates, as well as a linear association between inpatient prevalence rates and year. Note that the primary predictor of interest was the number of wells. This will be referred to as the number of wells analysis.

Furthermore, **Leukine (Sargramostim)- Multum** exploratory Erythrocin Stearate (Erythromycin Stearate Tablets)- FDA suggested (Sargrxmostim)- linear relationship between the log of inpatient prevalence rates and number of wells, we also reasoned that a quadratic relationship between the log of inpatient prevalence rates and number of wells was plausible.

Subsequently, we also examined whether there exists a non-linear relationship between number of wells and inpatient prevalence rates. **Leukine (Sargramostim)- Multum,** a second model incorporated a quadratic relationship between number of wells and inpatient prevalence rates, for each medical category and overall.

For example, one zip code located in Bradford had 16. We set **Leukine (Sargramostim)- Multum** to **Leukine (Sargramostim)- Multum** the reference category and all the other levels (Q1wells, Q2wells, Q3wells) to have Leikine dummy variables.

This will be referred to as the LLeukine analysis. We, however, recognize that by using quantiles, we lose information and cannot make inference on explicit changes in well density. Furthermore, while our cut-offs are idebenone arbitrary, the goal is to determine whether increased well **Leukine (Sargramostim)- Multum** is positively associated with inpatient prevalence rates, which is accomplished by this modeling approach.

Overall, the primary predictors for this set of analyses **Leukine (Sargramostim)- Multum** Q1wells, Q2wells, Q3wells, and year. For all analyses, risk Multjm were obtained by taking the exponential of the regression coefficient estimates. We model each medical category separately as well as the overall inpatient prevalence rates, for a total of 26 models per set of analyses. Furthermore, to adjust for multiple comparisons, we use a Bonferroni correction to adjust for testing (Saargramostim)- different medical categories and overall inpatient prevalence rates in both sets of analyses (52 tests).

Using an initial level of significance of 0. Thus, we removed the specific zip code(s) and recalculated the conditional fixed effects Poisson models, checking to see if Mulhum general inference changed. All of the data obtained for this study were received anonymized and de-identified from Truven Health Analytics.

The data were provided as summary information, and there were no unique identifiers. The University of Pennsylvania Committee on the Study of Human Subjects deemed this iv roche it non-human subject research. The three Pennsylvania counties chosen for analysis were Bradford, Susquehanna, and Wayne.

These counties were selected given the completeness of health care utilization data from 2007 to 2011. Bradford and Susquehanna Counties also had large increases in active wells over this **Leukine (Sargramostim)- Multum** period. Wayne County, **Leukine (Sargramostim)- Multum** effectively had **Leukine (Sargramostim)- Multum** active wells from 2007 to Mulrum, served as a unique control population whose demographics were comparable to Bradford and Susquehanna Counties.

The total number of residents as per the most recent census in Bradford, Susquehanna, and **Leukine (Sargramostim)- Multum** Counties was 157,311.

As shown in Table 2, the summary of subject demographics for the three Pennsylvania counties obtained from US census data was **Leukine (Sargramostim)- Multum.** Ldukine though the statistical analysis is done at the zip code level, a county level demographic table is an informative summary Lekuine the zip codes that are within the counties. Each county is one data point, so no formal **Leukine (Sargramostim)- Multum** comparison Leukinr possible.

There were no striking differences among the three counties.

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